Common Questions and Concerns about GLP-1 Medications
Medications can play an important role in weight management at MWM, but they are just one part of a comprehensive approach. You may have some questions or concerns about GLP-1s, so we are here to answer some common ones.
How do GLP-1 medications work?
GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide) are natural hormones that help regulate hunger, blood sugar, and digestion. These medications work by enhancing the effects of GLP-1 in the body. GLP-1 naturally regulates our hunger, blood sugars, and helps slow digestion. When GLP-1 is used in weight management, it can help to reduce hunger to control caloric intake, reduce blood sugars, and aid in weight loss.
What types of GLP-1s are available?
- Semaglutide: Wegovy® (injectable), Ozempic® (injectable), Rybelsus® (oral tablet)
- Tirzepatide: Zepbound® KwikPen (injectable), Mounjaro® (injectable). Note: These are combination drugs that combine GIP and GLP-1)
- Liraglutide: Saxenda® (injectable)
What are some of the common side effects of GLP-1 medications?
In addition to weight loss, many patients experience meaningful changes in how they feel day to day, including reduced “food noise” (fewer cravings and less constant thinking about food), as well as:
- Improved blood pressure
- Reduced blood sugars
- Reduced lipid disorders
- Improved liver markers
- Reduced risk for co-morbidities (i.e., heart disease, kidney disease, diabetes)
What are some of the common side effects of GLP-1 medications?
As with any medication, GLP-1s can have side effects. These are typically mild and often improve over time. The most common are gastrointestinal in nature, and may include:
- Loss of appetite
- Nausea
- Vomiting
- Diarrhea
- Constipation
- Headaches
These side effects can often be managed with guidance from your care team.
Less common side effects, such as changes in vision or hair loss, have also been reported and may be discussed in the media. Your healthcare provider can help you understand what is relevant to your individual situation.
Who benefits from being on a GLP-1?
GLP-1s like semaglutide, tirzeptide or liraglutide may be beneficial to individuals who:
- Have a BMI of greater than 30 or BMI of greater than 27 with obesity-related health concerns
- Have struggled to achieve lasting results with lifestyle changes alone
- Are looking for additional support to better manage hunger, eating patterns, and metabolic health
Which type of GLP-1 is right for me?
At MWM, we have obesity-trained physicians who will conduct thorough assessments to determine the best medication options for you. There is no one-size-fits-all approach, and the right choice depends on your health history, goals, and preferences.
We work with you every step of the way to ensure you remain comfortable while on these medications. If needed, medications may be adjusted, switched, or discontinued.
How long do I stay on these medications?
GLP-1 medications are intended for long-term use to treat obesity. However, the duration also depends on various factors like cost, ease of use, side effects, degree of improvement to weight loss, and quality of life.
It is important to note that stopping these medications may lead to weight regain, which is why ongoing support is important.
Considering GLP-1 Medications?
GLP-1 medications can be a helpful tool for some individuals, but they are most effective when used as part of a comprehensive, long-term approach to care.
If you are considering GLP-1 medications, speaking with a qualified healthcare provider is the best place to start. At MWM, our team can help you understand your options and develop a personalized plan that supports lasting results.
Resources
https://my.clevelandclinic.org/health/treatments/13901-glp-1-agonists